Combining asymmetric catalysis with natural product functionalization through enantioselective alpha-fluorination.
نویسندگان
چکیده
An examination into the derivatization of various natural products using newly developed alpha-fluorination methodology is disclosed. An activated ketene enolate, generated from an acid chloride, is allowed to react with an electrophilic fluorine source (NFSi). Quenching the reaction with a nucleophilic natural product produces biologically relevant alpha-fluorinated carbonyl derivatives of select chemotherapeutics, antibiotics, and other pharmaceuticals.
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عنوان ژورنال:
- The Journal of organic chemistry
دوره 75 3 شماره
صفحات -
تاریخ انتشار 2010